Oxygen free radical scavengers protect rat islet cells from damage by cytokines
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چکیده
منابع مشابه
Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice.
OBJECTIVE Tissue damage and endotoxemia in obstructive jaundice are attributed to the increase in oxygen free-radicals. We aimed at evaluating the possible protective effect of grape seed proanthocyanidin extract (GSPE), which is a potent exogenous free-radical scavenger and antioxidant. MATERIAL AND METHODS The study was performed at the Necmettin Erbakan University Meram School of Medicine ...
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M uch of what is considered critical illness may involve oxygen radical pathophysiology.'' Data accumulated from both experimental and clinical investigations have implicated oxyradical injury in the pathogenesis of pulmonary oxygen toxicity, adult respiratory distress syndrome (ARDS), bronchopulmonary dysplasia (BPD), sepsis syndrome , and a variety of ischemia-reperfusion syndromes, including...
متن کاملthe effects of simultaneous administration of nitric oxide and oxygen free radical scavengers on the isolated aortic tonus of rat
introduction: during the recent years many studies have been performed on the effects of nitric oxide andoxygen-derived free radicals (ofr) on the aorta, but there is no report on the effects of simultaneousmanipulation of both systems on the relaxation of this artery. material and methods: after anaesthesia, aortic rings from male rats (320-420 g) were obtained. thepieces of aorta were mounted...
متن کاملQuantitative Structure Activity Relationship Analysis of Coumarins as Free Radical Scavengers by Genetic Function Algorithm
The antioxidant properties of coumarin derivatives using the 2,2ˈ -diphenyl-1- picrylhydrazyl (DPPH) radical scavenging assay were investigated by the application of Quantitative Structure Activity Relationship (QSAR) studies. The molecular structures were optimized and submitted for the generation of quantum chemical and molecular descriptors. Genetic Function Algorithm (GFA) was employed in m...
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Tagetes mendocina (Asteraceae) is a medicinal plant widely used in the Andean provinces of Argentina. Preliminary assays showed free radical scavenging activity in the methanol extract of the aerial parts, measured by the decoloration of a methanolic solution of the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and scavenging of the superoxide anion. Assay-guided isolation led to 4'-hydroxyaceto...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1989
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00264909